01
In skin, bone and joints
Collagen is a fibrous protein that forms many tissues of the body, such as skin, bone, tendons, cartilage and blood vessels.
How much collagen each tissue contains
Clinically developed by a physician (MD, PhD)!
For happy,
heart-lifting
days.
Rich fish collagen
Dr.DECOLLA
Buy Now
Our Commitment
Our Five Commitments
Developed by
a physician100% natural
cod-skin collagenMade in Japan
No preservatives
or coloringsCareful quality
control
What Is Dr.DECOLLA?
A safe, non-hormonal supplement developed by a physician, for happy, heart-lifting days!
Clinically developed over 30 years by a leading collagen researcher:
a collagen × elastin jelly
- 100% natural cod-skin collagen
- 100% natural elastin from bonito bulbus arteriosus
- Jelly-like texture with a yuzu and honey flavor
Made with 100% natural cod-skin collagen and 100% natural bonito bulbus arteriosus elastin. A safe supplement made especially for women, with no female hormones. It supports the daily beauty routine of those who have begun to notice concerns about firmness or their body line.
Taking about two sachets a day is recommended as a beauty routine for those who wish to nurture a beautiful body line. As an easy-to-continue jelly, it makes inner care simple even on busy days. To maintain your body line, one sachet a day is recommended.
*Individual experiences may vary.
Get to Know the Structure of the Breast!
Connective tissue is
ECM = collagen and
elastin
The breast is made up of mammary glands, fat, Cooper's ligaments, connective tissue, and more. The connective tissue, known as the ECM, consists of collagen and elastin, and it is an important container that holds fat. When the connective tissue is weak, fat leaks out and is not retained. (This is the view set out in Dr. Ishii's U.S. patent application.)
* The above is quoted from Dr. Ishii's view and does not indicate any effect or efficacy of this product.
About Collagen
Collagen: what holds the body together
About 30% of the protein that makes up the body is collagen.1
02
How it changes with age
Data comparing skin collagen by age show a peak at 25–34, followed by a gradual decline of about 25% by 65–74. Another study of 76 women by decade found a significant decrease after the 40s.6,7
Skin collagen by age7
Over 4 decades~25%lower
Values are “Percent collagen score” (n = 64). Ages 25–34 and 65–74 are from the text; others are read from the figure. The original data come from a collagen ingredient manufacturer’s laboratory.
- Food Safety Commission of Japan
- Shin JW et al. (2019)
- Kannus P (2000)
- Fox AJS et al. (2009)
- Saito M. (2013)
- Castelo-Branco C et al. (1992)
- Reilly DM, Lozano J (2021), Figure 7
*Research findings do not indicate the effects or efficacy of any product.
Two Rare Ingredients:
The Unrivaled Beauty Components of Dr.DECOLLA
Derived from cod skin, tempered by
the cold, rough waves of the North Atlantic
Natural Collagen
Derived from the bonito bulbus arteriosus,
which supports the cycle of life in the Indian Ocean
Natural Elastin
Dr.DECOLLA was designed with a focus on the blend ratio of collagen and elastin. This ratio is modeled on the balance of collagen and elastin found in human connective tissue.
Our Commitment to Raw Materials
For this product, we were particular about our collagen and elastin raw materials from the very first stage of selection. For collagen, we use 100% natural cod skin, and we never use fish scales or salmon skin, as they are of lower quality. We chose our materials with careful attention to their origin and processing methods. For elastin, we use 100% natural bonito bulbus arteriosus.
Why Wild?
Collagen comes from many sources, such as cattle, pigs and fish. Using Japanese government statistics, we compared how much antimicrobial (antibiotics, etc.) is used for each.
Veterinary antimicrobial sales (Japan, 2024)
Tonnes of active substance
Pigs (skin)363
Farmed fish(salmon, tilapia, etc.)192
Cattle (hide, bone)95- Our raw material
Wild cod (skin)0None used
Source: MAFF National Veterinary Assay Laboratory, sales of veterinary drugs, 2024 (farmed fish = marine aquaculture; wild-caught fish receive none)
Cattle (hide, bone)
Raw materials from countries with BSE are subject to import rules
Farmed salmon
Antimicrobial use varies greatly by country: Norway about 0.5 t (2023), Chile about 351 t (2024)
Farmed tilapia
A study of farms in China found antimicrobials in feed and pond sediment
Dr.JAPAN chooses the skin of wild cod from the North Atlantic,
raised without antimicrobials.
*This compares raw materials and does not indicate the effects of any product. Sources: “Wild vs. Farmed Fish” / MAFF sales data / NORM-VET 2023 / Farias et al. 2025 / Zhou et al. 2021 / MHLW (BSE)
Comparing Collagen Sources
Collagen differs by source. Here is how the natural cod skin we use compares with other common sources.
| Our raw materialNatural cod skin | Fish scales | Pig skin | Cattle hide & bone | |
|---|---|---|---|---|
| Origin | North Atlantic (wild) | Varies by product | Varies by product | Varies by product |
| Denaturation temperature | about 18–22°C | about 24–37°C | about 41°C | about 35–40°C |
| BSE-related import rules | None | None | None | Yes (depends on the part) |
| Demineralization step | Not needed | Needed | Not needed | Needed for bone |
*Temperatures are from published studies and vary with species and method. This compares raw materials and does not indicate the effects of any product. Sources: “What Is Fish Collagen?”
Why Natural Cod Skin?
Fish collagen comes from many kinds of fish. Here is why we choose natural cod skin, compared with other common fish.
| Our raw materialNatural cod skin | Atlantic salmon skin | Tilapia skin & scales | |
|---|---|---|---|
| On Japan’s recommended allergen-labeling list | No | Yes (salmon) | No |
| Wild or farmed | Wild-caught Global catch: about 954,000 t (2023) | Almost all farmed Farmed: over 2.8 million t; wild catch: about 1,248 t (2023) | Mainly farmed About 5.3 million t worldwide (2022) |
| Demineralization step | Not needed | Not needed | Skin: not needed; scales: needed Calcium in scales is dissolved with hydrochloric acid, etc. |
| Dr. Hikaru Ishii’s research (patent, paper) | Used natural cod skin collagen | — | — |
*Allergen labeling shows only whether the fish is on the recommended list; it does not mean no allergy can occur. People with fish allergy should take care. This compares raw materials and does not indicate the effects of any product. Sources: “What Is Fish Collagen?” / Consumer Affairs Agency, allergen labeling / EUMOFA Atlantic cod / EUMOFA Atlantic salmon / FAO SOFIA 2024 / Feng et al. 2015 (scale demineralization)
Natural Cod Skin Needs No Demineralization
Collagen from fish scales requires a step called demineralization. Fish scales are made of hydroxyapatite (the calcium mineral also found in bone) and collagen fibers. To extract collagen from scales, this calcium must first be dissolved and removed. This step is called demineralization.
Scales
- Scales
calcium + collagen - Demineralize
dissolve calcium with HCl, etc. - Extract collagen
Our raw materialNatural cod skin
- Skin
- No demineralization
- Extract collagen
The natural cod skin we use has no calcium layer like scales do, so collagen can be extracted without a demineralization step that dissolves calcium with hydrochloric acid or other chemicals.
- Hydrochloric acid is commonly used. In a study of carp scales, soaking in 1.0 M HCl for 95 minutes removed about 93% of the minerals.
- EDTA can be used instead. It causes little collagen loss but removes minerals less efficiently than HCl.
- At high HCl concentrations fish collagen can dissolve, so conditions must be controlled.
*This describes how raw materials are processed and does not indicate the effects of any product. Source: Feng et al. (2015), J Food Sci Technol
Comparing Elastin Sources
Elastin also differs by source. Here is how the skipjack bulbus arteriosus we use compares with other common sources.
| Our raw materialSkipjack bulbus arteriosus | Pig | Cattle | Chicken | |
|---|---|---|---|---|
| Wild or farmed | Wild-caught | Livestock | Livestock | Livestock |
| Habitat | Warm open waters of the Indian Ocean (15–30°C) | Raised as livestock | Raised as livestock | Raised as livestock |
| BSE-related import rules | None | None | Yes (cattle-derived) | None |
*This compares raw materials and does not indicate the effects of any product. Sources: “What Is Elastin?”
Why Skipjack Bulbus Arteriosus?
Why we choose the skipjack bulbus arteriosus as our elastin source.
- 01
A wild fish
We use wild-caught skipjack. About 3.2 million tonnes are caught each year, the most of any tuna.
- 02
Not from cattle or pigs
For cattle- and pig-derived materials, concerns have been raised about diseases that pass from animals to people, such as BSE and foot-and-mouth disease. Fish-derived materials are used as an alternative.
- 03
Rich in elastin
The bulbus arteriosus at the outlet of the heart is reported to be rich in elastin. It is a by-product of processing.
*This describes the raw material and does not indicate the effects of any product. Sources: “What Is Elastin?” / Cai WW et al., Mar Drugs 2022 / Gaikwad S, Kim MJ, Mar Drugs 2024
Voices of Customers Who Tried It
Ms. A (20s)
It's sweet, tangy, and delicious! I was surprised that collagen could change my body line! My skin looks lovelier and my makeup goes on better, so it's two benefits in one. I'm so happy ♪
Ms. B (40s)
I reached my ideal, beautiful body in a healthy way! On top of that, my stiff shoulders felt easier and my body felt lighter, which was great. My skin and hair also gained firmness! I plan to keep using it!
*Individual results; personal impressions. These do not indicate the effects of the product.
Developer
Hikaru Ishii
Physician / MD, PhD
Hikaru Ishii, MD, PhD, the developer of Dr.DECOLLA, obtained an international patent on the prevention of arteriosclerosis using natural cod-skin collagen in 2011. In 2015, he reported a peer-reviewed paper on the improvement of carotid arteriosclerosis. He is currently conducting a clinical study for a U.S. patent application on bust enhancement.
Qualifications
- Physician
- MD, PhD
- Certified Occupational Physician, Japan Medical Association
- Lifetime Certified Physician in Gastroenterology, Japanese Gastroenterological Association
Society Membership
- Meritorious Member, Japanese Gastroenterological Association
Order Here!
Dr.DECOLLA
Price
¥6,600 (tax incl.)
1 bag (28 sachets), regular price ¥6,000 (excl. tax)
Ordering from outside Japan? See our International Shipping Guide
- We recommend two sachets a day, continued for two months.
- Jelly-like texture with a yuzu and honey flavor ♪
Frequently Asked Questions
How much is shipping?
¥600 (tax included; flat rate anywhere in Japan).
When will my order arrive?
We will ship your order within one week after your payment has been confirmed.
What is the best-before period?
Two years.
Do you ship overseas?
Yes, we do.
Please see our International Shipping Guide page.
Please see our International Shipping Guide page.