What differs between wild and farmed fish? Not whether one is bad for you, but what is used, compared with government statistics and research data.
Wild vs. Farmed Fish at a Glance
Key point: the difference is what is used
- FeedWild: finds its own foodFarmed: fed by people
- AntimicrobialsWild: none usedFarmed: may be used for disease
- FatWild: lowerFarmed: higher (all 4 fish compared)
Which drugs may be used on farmed fish is set by government, and the amounts vary greatly by country, species and farming method.
*This is not about which is better or worse for health. Knowing what is used, the choice is yours.
Farming raises young fish in pens or ponds with feed until shipment; wild fish grow in the sea or rivers and are caught. Main differences:
| Item | Wild | Farmed |
|---|---|---|
| Feed | Finds its own | Provided (fishmeal, fish oil, plant ingredients, etc.) |
| Antimicrobials | None used | May be used for disease; allowed drugs, doses and pre-shipment withdrawal periods are set by government |
| Fat (red sea bream, per 100 g) | 5.8 g | 9.4 g |
| EPA + DHA (red sea bream, per 100 g) | 910 mg | 1,300 mg |
| Labeling in stores (Japan) | No obligation (may say “wild” if true) | Fresh fish must be labeled “farmed” |
How Much Antimicrobial Is Used in Fish Farming?
Japan’s Ministry of Agriculture (MAFF) publishes annual sales of veterinary antimicrobials (antibiotics and synthetic antibacterials) for cattle, pigs, chickens, fish and other animals. The 2024 total was about 745 tonnes of active substance. By animal:
Veterinary antimicrobial sales in Japan (2024)
Tonnes of active substance
Pigs account for the most, followed by marine farmed fish. Sales for marine farmed fish rose from about 147 t in 2023 to about 192 t in 2024. The main drugs were oxytetracycline, erythromycin, ampicillin and sulfamonomethoxine.
The government sets which drugs may be used on farmed fish, with doses, methods and withdrawal periods before shipment. Since 2018, farmers in Japan need a written instruction from a specialist (such as a fish disease control officer) to buy antimicrobials, as part of national measures against antimicrobial resistance.
*Sales are the amounts reported by manufacturers multiplied by estimated shares per animal, and may differ slightly from actual use.
It Varies Greatly by Country (Farmed Salmon)
Even for the same farmed salmon, antimicrobial use differs greatly by country.
| Country | Year | Antimicrobials for farmed fish |
|---|---|---|
| Norway | 2023 | about 0.5 t (548 kg) |
| Chile | 2024 | about 351 t |
In Norway, use in farmed fish is lower than in land animals (about 4.5 t in 2023). In Chile, most use is to treat a bacterial salmon disease (piscirickettsiosis), with 97.9% given during the marine grow-out phase. When choosing farmed salmon, the country of origin is one useful guide.
Inspection of Imported Farmed Fish
Imported foods are checked by government monitoring for veterinary drug residues above set limits. When violations are found, inspections of that product from that country are strengthened. Examples for farmed fish:
| When | Product | Details |
|---|---|---|
| Dec 2022 | Snakehead from Thailand | Enrofloxacin violation; inspection rate raised to 30% |
| Nov 2024 | Farmed eel from China | Enrofloxacin violation; added to the monitoring plan |
Fat, EPA and DHA (Food Composition Tables)
Japan’s food composition tables list both wild and farmed values for some fish (raw, per 100 g edible portion). In all four, farmed fish had more fat and more EPA and DHA, and also more energy.
Fat content (wild vs. farmed)
g per 100 g edible portion
WildFarmed
| Fish | Energy per 100 g, wild / farmed | EPA + DHA per 100 g, wild / farmed | EPA + DHA per 1 g fat, wild / farmed |
|---|---|---|---|
| Ayu | 93 / 138 kcal | 147 / 620 mg | 61 / 78 mg |
| Olive flounder | 96 / 115 kcal | 410 / 690 mg | 205 / 186 mg |
| Red sea bream | 129 / 160 kcal | 910 / 1,300 mg | 157 / 138 mg |
| Bluefin tuna (lean) | 115 / 153 kcal | 147 / 1,420 mg | 105 / 187 mg |
EPA and DHA are components of fish fat, so fattier farmed fish contain more per 100 g. Per gram of fat the difference is smaller, and for olive flounder and red sea bream the wild fish have more.
*Per-gram-of-fat values are calculated from the food composition table figures.
The fat of farmed fish depends on its feed. A study of more than 3,000 Scottish farmed salmon found EPA + DHA fell from 2.75 g to 1.36 g per 100 g between 2006 and 2015 as fish oil in feed was replaced with plant oils, though levels were still higher than in most other fish.
*Composition also varies with season, location and size.
Tilapia Is Mostly Farmed
Tilapia is a largely farmed fish, with about 5.3 million tonnes produced worldwide (2022). Its skin and scales are also used as collagen raw materials.
A study of 20 ponds at 18 tilapia farms in southern China found quinolones even in feed from sealed bags, tetracyclines in feed from opened bags, and sulfonamides and quinolones in pond sediment. The authors concluded that antibiotic-free feed alone may not prevent overuse, and that measures such as veterinary prescriptions may be needed.
As a Collagen Raw Material
Collagen is made from pig and cattle skin and bone, and from fish skin and scales. Wild or farmed, by source:
| Source | Wild or farmed |
|---|---|
| Atlantic cod skin | Almost all wild; 2023 catch about 950,000 t, with about 1.2% farmed |
| Atlantic salmon skin | Almost all farmed (about 99.96%) |
| Tilapia skin and scales | Mainly farmed |
| Pig and cattle skin/bone | Livestock; in Japan, pigs receive the largest share of veterinary antimicrobials |
Dr.JAPAN uses collagen from the skin of wild cod caught in the North Atlantic. Wild fish grow without the feed or antimicrobials used in farming.
*Processed foods such as collagen products are not required to state whether the fish was wild or farmed. Ask the manufacturer if you want to know.
FAQ
Is farmed fish dangerous?
Which drugs can be used and how is set by government, and imports are inspected. This page does not judge safety; it lays out what is used, so you can choose.
Which is more nutritious?
In the four fish compared (ayu, olive flounder, red sea bream, lean bluefin tuna), farmed fish had more fat, and so more EPA and DHA per 100 g and more energy. Per gram of fat the difference is small, and wild olive flounder and red sea bream have more. Farmed fish composition depends on feed.
Does farmed salmon use a lot of antibiotics?
It depends greatly on the country: about 0.5 t for farmed fish in Norway (2023), about 351 t in Chile (2024).
How can I tell wild from farmed?
In Japan, fresh fish sold in stores must be labeled “farmed” if farmed. Processed products such as mixed sashimi platters or grilled eel have no such obligation.
Is wild fish free of any concern?
This page compares only feed, antimicrobials and fat. Wild fish vary in their own ways, for example by season and location.
Related Pages
Sources
- [1]MEXT, Standard Tables of Food Composition in Japan (8th ed., 2023)
https://fooddb.mext.go.jp/ - [2]MAFF, Aquaculture drugs, 39th edition (2026)
https://www.maff.go.jp/j/syouan/suisan/suisan_yobo/pdf/suisan_iyakuhin_ver.39.pdf - [3]Consumer Affairs Agency, Food Labeling Standards Q&A, Ch.3 Fresh foods
https://www.caa.go.jp/policies/policy/food_labeling/food_labeling_act/assets/food_labeling_cms201_260401_19.pdf - [4]MAFF National Veterinary Assay Laboratory, Sales of antibiotics and synthetic antibacterials (2024, 2023)
https://www.maff.go.jp/nval/iyakutou/hanbaidaka/index.html - [5]MAFF, Written instructions for aquaculture antimicrobials
https://www.maff.go.jp/j/syouan/tikusui/yakuzi/detail_torikumi.html - [6]NORM/NORM-VET 2023, Usage of antimicrobial agents and occurrence of antimicrobial resistance in Norway
https://www.fhi.no/en/publ/2024/norm-og-norm-vetusage-of-antimicrobial-agents-and-occurrence-of-antimicrobial-resistance-in-norwayny-side/ - [7]Farias DR, et al. Antibiotics 2025;14:1177
https://doi.org/10.3390/antibiotics14121177 - [8]MHLW notice on snakehead from Thailand (Dec 2022)
https://www.mhlw.go.jp/content/11135200/001022704.pdf - [9]MHLW notice on farmed eel from China (Nov 2024)
https://www.mhlw.go.jp/content/11135200/001340936.pdf - [10]Sprague M, et al. Sci Rep 2016;6:21892
https://www.nature.com/articles/srep21892 - [11]FAO, The State of World Fisheries and Aquaculture 2024
https://openknowledge.fao.org/server/api/core/bitstreams/1273bc36-339b-43d2-8163-af4d805f2ad2/content/sofia/2024/world-fisheries-aquaculture-production.html - [12]Gaikwad S, Kim MJ, Fish by-product collagen extraction using different methods and their application, Mar Drugs 22:60 (2024)
https://pmc.ncbi.nlm.nih.gov/articles/PMC10890078/ - [13]Zhou M, et al. Environ Pollut 2021;268:115854
https://doi.org/10.1016/j.envpol.2020.115854 - [14]Derkach SR et al., Polymers 12:3051 (2020), review
https://pmc.ncbi.nlm.nih.gov/articles/PMC7766531/ - [15]EUMOFA, Atlantic cod species profile (FAO data)
https://fishery-aquaculture-market-observatory.ec.europa.eu/en/country-and-species-profiles/species-profiles/atlantic-cod - [16]EUMOFA, Atlantic salmon species profile (FAO data)
https://fishery-aquaculture-market-observatory.ec.europa.eu/en/country-and-species-profiles/species-profiles/atlantic-salmon
This page provides general information and does not indicate the effects or efficacy of any product.