If Your Blood Vessels Stay Young, Your Healthy Lifespan Extends
Gentosha Publishing
12,000 copies sold
Founder's Message
Dr. Hikaru Ishii, Chairman
For more than five decades, I have dedicated my life to medicine, clinical research, and the pursuit of healthy longevity. As a physician specializing in internal medicine, I have accumulated 54 years of clinical experience, including 17 years of cancer immunotherapy research involving NK cell activation and more than 50,000 gastrointestinal endoscopic procedures. In parallel, I have devoted over 30 years to collagen research and supplement development.
In 2011, I obtained a European patent related to vascular health using natural fish skin collagen. That same year, while supporting the recovery of a young female patient with rib fractures through increased collagen supplementation, I made an unexpected clinical observation involving improvements in the décolleté area. This experience inspired a small clinical observation study at a women's clinic in Aoyama, Tokyo.
The findings led me to a broader hypothesis:
Healthy longevity and beauty may share the same biological foundation — the extracellular matrix (ECM).
The ECM is an essential structural environment that supports the organization and function of cells throughout the body. In my research, collagen and elastin appear to play particularly important roles in maintaining this structural integrity.
Currently, 50 subjects are under clinical observation, including participants from earlier studies. Preliminary observations have shown measurable changes in many evaluable participants, and a full U.S. patent application is planned following completion of the ongoing study.
Even at the age of 79, I continue to play tennis actively and maintain a highly demanding physical lifestyle. I personally believe that daily intake of high-quality collagen has contributed significantly to maintaining my connective tissue integrity and overall vitality.
For me, this research is not simply about beauty.
It is about helping people maintain confidence, vitality, and quality of life as they age.
My mission is to continue exploring the relationship between ECM health, healthy longevity, and physical well-being, and to share these findings with people around the world.
Dr. Hikaru Ishii (age 79) serving at 150 km/h
Publications by Dr. Hikaru Ishii
About our publications and sales figures
The Lies of Doctors
Gentosha Publishing
120,000 copies sold
The Doctor's Crime and Punishment
Gentosha Publishing
8,000 copies sold
ANK
Immune Cell Therapy When Diagnosed with Cancer
Gentosha Publishing
8,500 copies sold
Profile
Education
| 1972 | Graduated from Nippon Medical School |
|---|---|
| 1972 | Passed the Japanese National Medical Examination |
| 1983 | Doctorate Degree (Ph.D.) awarded |
Professional Experience
| 1972 | Tokyo Women's Medical University — Surgical Resident |
|---|---|
| 1974 | Saitama Medical University — Assistant, Third Department of Internal Medicine |
| 1977 | Josai Dental University — Part-time Lecturer in Internal Medicine |
| 1977 | Asahigaoka Hospital — Vice Director and Board Member |
| 1987 | Mount Sinai Hospital, USA — Visiting Research Fellow and Instructor |
| 1993 | Mizuno Memorial Hospital — Director of Internal Medicine |
| 1996 | Shin-Nihonbashi Ishii Clinic — Chairman and Medical Director |
| 2022 | Okachimachi Ekimae Internal Medicine Clinic — Director |
| 2023 | Shibaura Clinic — Director |
| 2026 | Urayasu Takayanagi Hospital — Internal Medicine Physician |
Certifications & Academic Affiliations
| Certification | Certified Occupational Physician, Japan Medical Association |
|---|---|
| Specialty | Certified Gastroenterology Specialist |
| Former Role | Councilor, Japanese Society of Gastroenterology |
| Membership | Distinguished Service Member, Japanese Society of Gastroenterology |