Natural Fish Skin Collagen Clinical Study
Fish Skin Collagen Clinical Study
This clinical study, conducted by Dr. Hikaru Ishii, investigates natural fish skin collagen intake in relation to the shape and structural support of the décolleté area.
It is grounded in the hypothesis that ECM (extracellular matrix) integrity represents a shared biological foundation for both healthy longevity and beauty.
The research described here does not indicate the effects or efficacy of any product.
01Background
In 2011, after increasing collagen intake for a young female patient with rib fractures, Dr. Ishii made an unexpected clinical observation involving the décolleté area. This discovery led to a small clinical observation study involving 14 participants at a women's clinic in Aoyama, Tokyo.
This observation evolved into a broader hypothesis: the Cooper's ligaments of the breast are rich in elastin, and when ECM integrity is reinforced, it may prevent sagging and contribute to a better-defined décolleté contour.
02Current Research Status
- Research Resumed
- 2025
- Total Subjects
- 50 (including participants from 2011 study)
- Evaluable Results
- 26 out of 30 subjects (86.7%) showed measurable improvement
- Final Results
- Expected by June 2026 (all 50 subjects)
- Patent
- Full U.S. patent application planned upon completion
- Principal Investigator
- Dr. Hikaru Ishii, M.D., Ph.D.
Research is ongoing. This page will be updated when final results become available.
03Collagen Source
Natural Cod Fish Skin
The collagen used in this research is derived from natural cod fish skin through enzymatic processing.
Elastin
For elastin, naturally derived elastin from bonito (skipjack tuna) arterial bulbs is considered optimal in our research formulations.
For the difference between fish skin and fish scale collagen, see What Is Fish Collagen?
Dr. Ishii obtained a European patent in 2011 for the use of natural fish skin collagen in improving arterial health. The décolleté collagen research is a direct extension of that work.
The research described here does not indicate the effects or efficacy of any product.
For questions about our products
or research, please contact us.