01
In skin, bone and joints
Collagen is a fibrous protein that forms many tissues of the body, such as skin, bone, tendons, cartilage and blood vessels.
How much collagen each tissue contains
Extend healthy lifespan,
support lasting beauty.
An ECM-based approach grounded in
natural fish skin collagen research
ChairmanDr. Hikaru IshiiMD, PhD
54yrs
Clinical experience
634cases
NK cell therapy
50,000+
Endoscopies
2011
European patent
Dr.JAPAN Official Channel
Featured videos
Behind the scenes of our research, in short videos.
Visit our channelResearch for everyday life.
-
01
NK Cell Therapy
Clinical StudyCancer immunotherapy research
through NK cell activation,
built on 17 years and 634 cases. -
02
Fish Skin Collagen
Clinical StudyHuman clinical research
using natural fish skin
collagen. -
03
Healthy Longevity
Extending the years of
independent living, from the
perspective of ECM.
*Research findings do not indicate the effects or efficacy of any product.
About Collagen
Collagen: what holds the body together
About 30% of the protein that makes up the body is collagen.1
02
How it changes with age
Data comparing skin collagen by age show a peak at 25–34, followed by a gradual decline of about 25% by 65–74. Another study of 76 women by decade found a significant decrease after the 40s.6,7
Skin collagen by age7
Over 4 decades~25%lower
Values are “Percent collagen score” (n = 64). Ages 25–34 and 65–74 are from the text; others are read from the figure. The original data come from a collagen ingredient manufacturer’s laboratory.
- Food Safety Commission of Japan
- Shin JW et al. (2019)
- Kannus P (2000)
- Fox AJS et al. (2009)
- Saito M. (2013)
- Castelo-Branco C et al. (1992)
- Reilly DM, Lozano J (2021), Figure 7
*Research findings do not indicate the effects or efficacy of any product.
Our Commitment
Our Five Commitments
Developed by
a physician100% natural
cod-skin collagenMade in Japan
No preservatives
or coloringsCareful quality
control
*Applies to Dr.DECOLLA and Dr.Energy Collagen EX.
From our research
Dr.DECOLLA
Dr.DECOLLA
- No hormone-like ingredients
- Natural cod skin collagen
× bonito arterial bulb elastin - 28 sachets
Dr.Energy
Collagen EX
Dr.Energy Collagen EX
- Natural fish collagen
- Collagen + calcium + elastin
- 28 packs
About Zinc
Zinc: an essential mineral
Zinc is a mineral that makes up many of the enzymes at work in the body.1
01
More people fall short with age
The adult body holds about 2 g of zinc, used in hundreds of enzymes. By age, the share of people whose blood zinc falls below the normal range rises, reaching about 90% at age 80+.1,2
Blood zinc levels by age2
20s
30s
40s
50s
60s
70s
80+
- Deficient (<60 μg/dL)
- Marginal (60–80)
- Normal (≥80)
Share (%) among 13,100 patients aged 20+ whose serum zinc was measured at hospitals across Japan (2019–2021). Categories follow the Japanese Society of Clinical Nutrition guideline (normal 80–130 μg/dL).2,3
02
Intake changes with age
Men’s daily zinc intake from meals declines after their 60s. Over the same ages, the share of people with deficient blood zinc (<60 μg/dL) rises from about 20% in their 40s to about 50% at 80+.2,4
Zinc intake and share of deficiency by age2,4
Men (intake)Women (intake)
- Kenko Choju Net, "Zinc"
- Yokokawa H et al. (2024), Table 2
- Japanese Society of Clinical Nutrition, Zinc Deficiency Guideline 2018
- MHLW, National Health and Nutrition Survey 2023, Part 1 Table 1 (by age)
*This explains the nutrient and survey data; it does not indicate the effects or efficacy of this product.
Eastern and Western wisdom for everyday wellness.
Dr.ACIS
Dr.ACIS
Quality for your everyday wellness.
A zinc complex jelly
- Natural
botanicals - Original blend of
East & West herbs - For healthy
everyday life - Supervised by
physicians
Dr.DECOLLA is read "Doctor Decolla". See the product page for its ingredients and other details.
These are general food products. No effect or efficacy is claimed.
About Dr.JAPAN
About Us
Advancing healthy longevity and beauty science — Dr. Hikaru Ishii, MD, PhD
Dr.JAPAN focuses on extracellular matrix (ECM) health, supporting vibrant living through clinical research on natural fish skin collagen and evidence-based product development.
Dr.JAPAN Co., Ltd. is dedicated to advancing healthy longevity and beauty science through rigorous clinical research on natural fish skin collagen.
Our founder, Dr. Hikaru Ishii, brings over 54 years of clinical experience, including a European patent for collagen-based vascular health, 17 years of NK cell immunotherapy (634 cases), and more than 50,000 gastrointestinal endoscopic procedures.
Guided by the hypothesis that healthy longevity and beauty share the same biological foundation — the extracellular matrix (ECM) — we conduct research and develop food products.
Beyond research, for every day of your life.
Turning clinical insight into research and products that support daily health.
ChairmanDr. Hikaru Ishii
Publications
Books by Dr. Hikaru Ishii
About our publications and sales figures
-
120,000 copies
Gentosha
The Lies of Doctors
-
12,000 copies
Gentosha
If Your Blood Vessels Stay Young,
Your Healthy Lifespan Extends -
8,500 copies
Gentosha
ANK — Immune Cell Therapy
When Diagnosed with Cancer -
8,000 copies
Gentosha
The Doctor's Crime
and Punishment
Our Team
Hikaru Ishii
Chairman, MD, PhD
Reo Ishii
President, Physician
Akira Nishimura
Clinical development
For questions about our products
or research, please contact us.